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5 Best Acetaminophens of 2025

Last Updated - 2025/07/23

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol

Tylenol Extra Strength 500 mg eZ Tab, Pack of 2 (300tab Total)

Tylenol

CA$28.56

CA$30.34
(5% Off)

More Details
Main highlights
- Tough on pain, easy on your stomach
- NEW amazon exclusive 2-Pack includes two bottles of 150 count for 300 total eZTABS
- Fast, effective relief of headaches, aches and pain, and fever
- Extra Strength Formula & Easy-to-swallow tablets
- Contains the pain reliever/fever reducer acetaminophen
CA$28.56
CA$30.34 (5% Off)
2
Best Value
12% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

GenCare
12% Off

GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (200 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic Excedren Extra Strength

GenCare

CA$26.30

CA$30.00
(12% Off)

More Details
Main highlights
- HUGE SAVINGS - Save big compared to big box stores and your local pharmacy with effective over the counter relief with our bulk size 300 caplet value bottle. Always be prepared and in stock with effective pain relief pills on hand for when your family needs it the most. Compare to generic Excedren Extra Strength active ingredients.
- HELPS WITH ACHES & PAINS - Relieve Back pain, neck pain, toothaches, menstrual cramps, arthritis, joint pain and more in one easy to swallow caplet. Directions: Adults and children 12 years and older : take 2 caplets every 6 hours . Do not exceed 8 caplets in a 24 hour period.
- HEAD & BODY PAIN RELIEF - Each caplet of GenCare Extra Strength Headache Relief contains 250mg of Acetaminophen, 250mg of Aspirin (NSAID) and 65 mg of Caffeine to give fast and extended pain relief of headaches, muscle aches, back pain and migraines.
- ACTS FAST - Headaches, migraines and pain can hit at the worst time. 65 mg of caffeine in each pill help energize you and restore mental focus so you can accomplish the task at hand. 65 mg of caffeine is about as much a cup of coffee, so avoid this product before bed.
- 100% SATISFACTION GUARANTEE - Say goodbye to headaches and pain! GenCare backs up each bulk savings bottle of Extra Strength Headache Relief with our 100% Customer Satisfaction Guarantee. Join thousands of satisfied customers.
CA$26.30
CA$30.00 (12% Off)
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Stanley Pharmaceuticals

Stanley Pharmaceuticals Arthritis Pain Relief Tablets USP 650 Mg 100 count(packaging might vary)

Stanley Pharmaceuticals

CA$16.49

More Details
Main highlights
- Up to 8 hour relief
- Relieves minor muscular aches, pains & strains
- Relieves menstrual cramps & headaches
- Relieves arthritis pain
- Relieves aches and pains due to flu and fever
CA$16.49
4

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol

Tylenol Extra Strength For Pain Relief, Headache Relief, and Reducing Fever, 500 mg Acetaminophen 100 eZTABS

Tylenol

CA$11.37

More Details
Main highlights
- PAIN RELIEVER & FEVER REDUCER: Contains the pain reliever/fever reducer medicine acetaminophen
- FAST & EFFECTIVE RELIEF: Provide fast, effective relief of headaches, aches and pain, fever, mild to moderate migraine and arthritis pain and menstrual cramps
- EXTRA STRENGTH & EASY-TO-SWALLOW TABLETS: Extra strength formula and easy-to-swallow tablets, 100 count
- CONTAINS ACETAMINOPHEN: Tylenol Extra Strength Acetaminophen 500mg eZ Tablets are tough on pain, easy on your stomach
- CLINICALLY PROVEN: Clinically proven fast pain relief
CA$11.37
5

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol

Tylenol Extra Strength For Pain Relief, Headache Relief, and Reducing Fever, 500 mg Acetaminophen 150 Caplets

Tylenol

CA$14.38

CA$15.97
(9% Off)

More Details
Main highlights
- TYLENOL Extra Strength Acetaminophen 500mg Caplets act quickly to provide effective relief and is unlikely to cause stomach upset.
- PAIN RELIEVER & FEVER REDUCER: Contains the pain reliever/fever reducer medicine acetaminophen
- FAST & EFFECTIVE RELIEF: Provide fast, effective relief of headaches, aches and pain, fever, mild to moderate migraine and arthritis pain and menstrual cramps
- EXTRA STRENGTH & EASY-TO-SWALLOW TABLETS: Extra strength formula and easy-to-swallow tablets, 150 count
- CONTAINS ACETAMINOPHEN: Tylenol Extra Strength Acetaminophen 500mg Caplets are tough on pain, easy on your stomach
- CLINICALLY PROVEN: Clinically proven fast pain relief
CA$14.38
CA$15.97 (9% Off)

5 Best Acetaminophens of 2025

Tylenol Extra Strength 500 mg eZ Tab, Pack of 2 (300tab Total)

GenCare - Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (200 Caplets) Value Pack | Head Pain, Muscle Aches, Back Pain & Body | Generic Excedren Extra Strength

Stanley Pharmaceuticals Arthritis Pain Relief Tablets USP 650 Mg 100 count(packaging might vary)

Tylenol Extra Strength For Pain Relief, Headache Relief, and Reducing Fever, 500 mg Acetaminophen 100 eZTABS

Tylenol Extra Strength For Pain Relief, Headache Relief, and Reducing Fever, 500 mg Acetaminophen 150 Caplets

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Extra Strength Tylenol Daytime Relief Tablets, 500 mg Acetaminophen + 65 mg Caffeine, Morning Headache & Pain Relief, 80 Tablets

Tylenol Regular Strength For Pain Relief, Headache Relief, and Reducing Fever, 325 mg Acetaminophen Caplets

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